RANDOMIZED CONTROLLED CLINICAL STUDY OF GANDIRADI TAIL IN THE MANAGEMENT OF DUSHTA VRANA WITH SPECIAL REFERENCE TO INFECTED WOUND

Wound is a common encountered problem faced in a surgical practice. Treatment ofwound healing is probably the first medical problem faced by a human being. Treatmentof Dushtavrana is one of them. According to Sushruta Acharya Vrana is of two types Nijaand Agantuj. Acharya Sushrut considered Vrana as a prime disease in the domain of surgeryand that is why he has described 60 measures for wound management. Treatment with localapplication of Gandiradi tail have shown effective result during and post follow up oftreatment in reducing sign and symptoms. The aim and objective of this clinical study is toevaluate efficacy of a local application of Gandiradi tail in the management of Dushtavrana.Total 66 patints were selected as open random clinical study, out of 66 patients, 33 patientswere treated by application of Gandiradi tail and 33 patients were treated by application ofNirgundi tail for 7 days daily and assessment was done on 3rd, 5th, 7th and 14th day. Both thedrug found effective in the management of infective wound. The percentage of patients of thehealed wound was 48.48% in Gandiradi's Taila and 36.36% in Nirgundi Taila.

Suddhavarna which if delayed in proper Chikitsha may get converted to Dustavrana.

Vrana is
Gatravichurne, Vranayateti Vranah. [3] In this "Gatra" mean body, Vichurne means destruction, break, rupture and discontinuity. The destruction break or discontinuity of body part is called "Vrana." Wound is a break in integrity of the skin or tissue often, which may be associated with distruption of structure and function. Wound healing is a body response to injury in an attempt to restore normal structure and function. Wound healing is divided in three phase inflammatory phase, proliferative phase, and remodeling phase.
Nija Vrana due to Doshas and Agantuj vrana are caused by shrap weapons, stone, poison etc. In Ayurveda simulates ulcers or wound; which may get converted into Dushta vrana i.e infectious or complicated wound in due course of time if left untreated. Sushruta has explained sixty measure for wound management. Precise management of Dushta Vrana has been described in various ayurvedic texts. Many formulation are in use for centuries for Dushta vrana. One of these is described in Chakradatta is Gandiradi tail. The objective of study is to evaluate the effect of Gandiradi tail on the basis of relief of sign and symptoms of Dushta Vrana. All content of Gandiradi tail are Ushna virya and Tikta-Katu Ras Pradhan so its effect is Kaphvatshaman, Vranasodhan and Vranropan so helps in wound healing process. According to Materia Medica, the contents of Gandiradi Tail drugs has antiseptic, anti-inflammatory, and disinfectant properties so ultimately help to wound heals faster.

AIM:
To study the wound healing effect of Gandiradi Taila in the management of Dushta Vrana with special reference to an infected wound.

OBJECTIVES: Primary Objectives:
To study the wound healing effect of Gandiradi Tail local application for 7 days in comparison with Nirgundi Tail in Dushta Vrana with special reference to an infected wound.

MATERIAL AND METHOD:
A complete clinical examination of the patient's general condition and examination of Vrana had been done on the day first of examination. In the trial group, Gandiradi tail has been taken for study and in the control group Nirgundi tail has been taken for the study. The dressing is done by the local application of Gandiradi Taila and Nirgundi Taila with soaked gauze for 7 days daily. Patients undergoing study were examined clinically in every follow-up & record was maintained.

Drug -Gandiradi Tail
Route -Local application (Dressing) of Gandiradi Tail with sterile gauze.

Drug-Nirgundi Tail
Route -Local application (Dressing) of Nirgundi Tail with sterile gauze.
Duration -Once daily for 7 days Procedure: The first wound was cleaned with N.S. then it was dried with a sterile pad. Then gauze soaked Tail was applied on the wound and dressing was done.