Comparative study of efficacy of Aragvadha (cassia fisula linn.) Patra Lepa and Conate ointment in dinitroflurobenzene induced allergic eczema in balb/c mice

Abstract

Skin is the largest organ of the integumentary system. Skin play an important immunity role in protecting the body against pathogen and excessive water loss. Under the heading of ‘Kushtha’ Ayurveda has described all skin diseases. In Ayurveda, there are Kushtha, Kshudra roga and Visarpa are three major groups of diseases in which skin get affected. Vicharchika is one among eleven kshudra kushtha which has a chronic course. It is considered as difficult to cure and even if is cured relapses are found to be common.  Vicharchika can be simulated with the diseases Eczema/ Dermatitis. Eczema or Dermatitis is a common problem in all age group all over the world. Visha, especially toxins created in our body from unusual dietary habits are considered to be a major causative factor for Vicharchika.

Presently, the potent topical or systemic corticosteroids and anti-histaminic are the main stay in this condition however; they have serious adverse effects and have limitations for a long term therapy. Hence, there is a need for drugs having good efficacy with low toxic profile in this debilitating disorder. Aragvadha patra (Cassia fistula leaves) Lepa, is one such formulation which is used in vicharchika.

To avail a new easier formulation to mankind for vishajanya vicharchika, Aragvadha patra lepa topic has been selected for the study.